Nitric Oxide Inhibits Closure of the Ductus Arteriosus following Antenatal Exposure to Indomethacin † 982

ductus arteriosus with indomethacin

The effect of indomethacin treatment of patent ductus arteriosus (PDA) on blood pressure was studied in 24 preterm infants. PDA was diagnosed clinically and confirmed by echocardiography; the effect of treatment was monitored echocardiographically. Hourly intra-arterial recordings of systolic, diastolic, and mean blood pressure were averaged for the 48 hours before the first dose of indomethaci...

Intravenous Paracetamol and Patent Ductus Arteriosus Closure

Background: Standard medical treatments for patent ductus arteriosus (PDA) closure are, including indomethacin/ibuprofen and surgical ligation. Nowadays, a new strategy to close PDA is the use of paracetamol. The present study aimed to describe the use of intravenous (IV) paracetamol for PDA closure in neonates who present a contraindication to ibuprofen or ibuprofen failure with no possibility...

Pharmacological closure of ductus arteriosus in preterm infants using indomethacin.

Patent ductus arteriosus (PDA) was diagnosed in 27 (21 %) of 129 infants weighing < 1500 g at birth presenting over I years. The incidence ofPDA in infants with pulmonary disease, particularly hyaline membrane disease, was higher than that in infants without such disease (31% compared with 16%). 16 (59%) infants with PDA developed congestive cardiac failure (CCF), of whom 12 were <1000 g at bir...

Indomethacin induced ductus arteriosus closure in midgestation fetus

This article reports a rare but potentially serious complication of ductus arteriosus closure resulting from second-trimester indomethacin exposure. Serial echocardiograms are indicated to monitor for development of right heart dysfunction and to ensure delivery prior to the onset of right heart failure and hydrops fetalis.

Closure of Small Patent Ductus Arteriosus by Occluding Detachable Coil